DrPlus Skin Education · Singapore
Profhilo vs Rejuran vs Skin Boosters: A Singapore Guide
Three injectable 'skin quality' treatments, three different mechanisms. This guide separates bio-remodelling, polynucleotide repair and micro-droplet hydration so you can match the tool to your skin.
Three different mechanisms, one shared goal
All three treatments sit in the 'skin quality' family: injectables that improve how skin looks and behaves rather than adding shape or freezing movement. But mechanistically they are distinct — and matching mechanism to concern is the entire game.
Profhilo is ultrapure hyaluronic acid at high concentration, thermally stabilised so it spreads through tissue and stimulates collagen and elastin (bio-remodelling). Rejuran's polynucleotides are DNA-derived fragments associated with tissue repair processes. Classic skin boosters deposit micro-droplets of cross-linked HA that hold water where they sit.
Mechanism
Profhilo — bio-remodelling
Spreads across tissue planes from a few injection points, stimulating collagen and elastin. Targets crepiness, laxity, overall firmness.
Mechanism
Rejuran — repair
Polynucleotides support the skin's repair environment. Discussed for post-acne texture, barrier recovery, and the under-eye area.
Mechanism
HA boosters — hydration
Micro-droplets of hyaluronic acid bind water in the skin. Targets dehydration, dullness, fine dry lines and glow.
The practical side-by-side
Beyond mechanism, the treatments differ in protocol, sensation and downtime — the practical factors that shape whether a course fits your life and budget.
— Comparison
Profhilo vs Rejuran vs HA boosters
| Profhilo | Rejuran | HA boosters | |
|---|---|---|---|
| Primary target | Laxity, elasticity, overall quality | Repair, texture, under-eye | Hydration, fine lines, glow |
| Initial course | 2 sessions, ~1 month apart | 3–4 sessions | 2–3 sessions |
| Injection pattern | Few points (BAP technique) | Many micro-injections | Many micro-droplets |
| Typical downtime | Small temporary bumps at points, hours to a day | Micro-bumps and redness, commonly 1–3 days | Micro-bumps and redness, commonly 1–2 days |
| Maintenance | ~6-monthly | ~6–12-monthly | ~6–9-monthly |
Primary target
- Rejuran
- Laxity, elasticity, overall quality
- HA boosters
- Repair, texture, under-eye
- Hydration, fine lines, glow
Initial course
- Rejuran
- 2 sessions, ~1 month apart
- HA boosters
- 3–4 sessions
- 2–3 sessions
Injection pattern
- Rejuran
- Few points (BAP technique)
- HA boosters
- Many micro-injections
- Many micro-droplets
Typical downtime
- Rejuran
- Small temporary bumps at points, hours to a day
- HA boosters
- Micro-bumps and redness, commonly 1–3 days
- Micro-bumps and redness, commonly 1–2 days
Maintenance
- Rejuran
- ~6-monthly
- HA boosters
- ~6–12-monthly
- ~6–9-monthly
Choosing by concern, not by popularity
If your main complaint is early laxity, crepiness or 'tired-looking' skin quality, bio-remodelling is usually the conversation to start with. If it is post-acne texture, sensitivity-prone or damaged skin, or fine crepe under the eyes, polynucleotides come to the front. If it is dryness, dullness and fine dehydration lines, a classic booster does exactly that job.
Combinations are common over a year of care — for example a repair-focused course followed by bio-remodelling — but they should be staged deliberately by a doctor, not stacked in one enthusiastic visit. Budget follows the same logic: complete one well-chosen course before adding the next. Our companion guide to skin booster cost factors in Singapore covers the course economics in detail.
Skin-quality consultations at DrPlus Singapore
At our Tanjong Pagar and East Coast clinics, the doctor examines your skin — hydration, texture, laxity, barrier condition — and maps which of the three families (or which sequence) addresses your concern. You leave the consultation with a specific protocol and its full cost, and results are reviewed as your skin responds. Individual results vary, and suitability is confirmed in person.
— Frequently asked
Common questions
The under-eye is where polynucleotide (Rejuran-type) treatment is most often discussed, because the skin there is thin and repair-focused treatment suits it. Profhilo has specific protocols for some zones too. The honest answer depends on what your under-eye issue actually is — crepiness, darkness, or hollowing — which a doctor distinguishes at assessment.
They can be staged in a treatment plan since they do different jobs, but sequencing and spacing are doctor decisions. Completing one course and reviewing the response before starting the next is the disciplined (and usually more economical) approach.
Compare per completed course, not per session: Profhilo is typically two sessions, Rejuran three to four, HA boosters two to three, each with different per-session pricing and maintenance cadence. A consultation gives you the full-course numbers for your skin rather than a misleading single-session comparison.
All three build gradually: hydration changes can appear within days to weeks, while collagen-related firmness develops over one to two months after the course. These are progressive skin-quality treatments — not instant-change procedures — and individual response varies.
DrPlus offers doctor-led Profhilo, Rejuran and HA skin booster treatment at SBF Center in Tanjong Pagar and The Flow Mall on East Coast Road. The consultation matches the product family to your skin before any course is priced.
— Related treatments
Continue with the relevant DrPlus treatment pages
Each page goes deeper into mechanism, suitability and recovery — your final plan is confirmed at consultation.
— Continue reading
Skin Booster & Profhilo Cost in Singapore: What Determines It
Skin boosters are course-based treatments, so single-session prices mislead. This guide explains the protocols behind Profhilo, Rejuran and HA boosters — and how their costs really compare.
First Time Considering Injectables? A Singapore Starter Guide
Anti-wrinkle injections, fillers, skin boosters — the injectable menu is confusing from the outside. This guide maps the categories to the concerns they treat and shows what a sensible, safe first step looks like.
Skin Tightening in Singapore: HIFU, RF Microneedling & Biostimulators Compared
Four very different technologies all sell themselves as 'skin tightening'. Here is what each one actually does, who it suits, and how a doctor picks between them.